HIV-associated neurocognitive disorder (HAND) encompasses a spectrum of neurological conditions that can arise when HIV enters the central nervous system. This can manifest as mild cognitive impairment, affecting memory and concentration, or progress to more severe forms like HIV-associated dementia, characterized by significant cognitive decline, motor dysfunction, and behavioral changes. The virus can infiltrate the brain early in the course of infection, even when systemic symptoms are minimal or well-controlled by antiretroviral therapy.
Understanding the spectrum of HAND is crucial for effective management of HIV. Early detection allows for timely interventions that can mitigate neurological damage and improve quality of life for individuals living with HIV. While antiretroviral therapies have significantly reduced the incidence of severe forms of HAND, milder forms remain prevalent. The ongoing research into the mechanisms of HIV neuroinvasion and the development of neuroprotective strategies are essential for further reducing the burden of HAND.