This laboratory procedure analyzes blood serum for antibodies specifically targeting deamidated gliadin peptides, a component of gluten. These antibodies (immunoglobulin A, or IgA) are produced by the immune system in individuals with celiac disease and gluten sensitivity. The levels of these antibodies are measured and reported as a numerical value, along with a qualitative interpretation (e.g., positive, negative, equivocal). For instance, a high level of these specific antibodies typically suggests an immune reaction to gluten.
Accurate analysis of these test results provides valuable information for diagnosing and managing gluten-related disorders. This method offers increased sensitivity and specificity compared to older gluten antibody tests, leading to improved detection rates, especially in cases of less severe or atypical presentations. This advancement contributes to earlier diagnosis and intervention, which can significantly improve patient outcomes by reducing the risk of long-term complications associated with untreated celiac disease.
